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proG [2017-08-22 12:01:45]
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proG [2017-08-22 12:01:45]

1-pyrroline-5-carboxylate dehydrogenase
locus
BSU12910
pI
4.91
mw
30.05 kDa
protein length
272 aa Sequence Blast
gene length
816 bp Sequence Blast
function
biosynthesis of proline
product
1-pyrroline-5-carboxylate dehydrogenase
essential
no
ec
1.5.1.2
synonyms
ykeA,yzcA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.2|Biosynthesis/ acquisition of proline]

    • Gene

    Coordinates
    1,359,454 → 1,360,272

    The protein

    Catalyzed reaction/ biological activity

  • 1-pyrroline-5-carboxylate + NADPH + H+ --> L-proline + NADP+ [pubmed|28824574]

    • Protein family

  • pyrroline-5-carboxylate reductase family (according to Swiss-Prot)

    • [SW|Cofactors]

  • NADPH [pubmed|28824574]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|63AFCEE5DEA6B2604C02592C5FB52EDFAE68913E|proG]
    description
    [Pubmed|1766370,21784929]
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    Biological materials

    Mutant

  • MGNA-B308 (ykeA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1307 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 25367752

    • Original publications

  • 11418582,1766370,21784929,28752945,28824574